[HTML][HTML] Genome-wide association studies

E Uffelmann, QQ Huang, NS Munung… - Nature Reviews …, 2021 - nature.com
… GWAS often require very large sample sizes to identify reproducible genome-wide significant
associations and the desired sample size can be determined using power calculations in …

Status and prospects of genomewide association studies in plants

L Tibbs Cortes, Z Zhang, J Yu - The plant genome, 2021 - Wiley Online Library
… Continued progress in sequencing technologies and coordinated community effort have
made genome-wide association studies (GWAS) a method of choice, particularly when …

Advancing the use of genome-wide association studies for drug repurposing

WR Reay, MJ Cairns - Nature Reviews Genetics, 2021 - nature.com
Genome-wide association studies (GWAS) have revealed important biological insights
into … , transcriptome-wide association studies, gene-set association, causal inference by …

Interpretation of risk loci from genome-wide association studies of Alzheimer's disease

SJ Andrews, B Fulton-Howard, A Goate - The Lancet Neurology, 2020 - thelancet.com
… the causal gene in known loci identified in genome-wide association studies. Rare genetic
variant analyses in Alzheimer's disease have identified coding variants located within PLD3, …

An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank

SM Smith, G Douaud, W Chen, T Hanayik… - Nature …, 2021 - nature.com
… Previously, we published genome-wide associations of 3,144 brain imaging-derived … Here
we present a new open resource of genome-wide association study summary statistics, using …

Genome-wide association studies for Alzheimer's disease: bigger is not always better

V Escott-Price, J Hardy - Brain Communications, 2022 - academic.oup.com
… disease genome-wide association studies. We observe that nearly all earlier … genome-wide
association studies are now part of all current disease genome-wide association studies

The power of genetic diversity in genome-wide association studies of lipids

SE Graham, SL Clarke, KHH Wu, S Kanoni, GJM Zajac… - Nature, 2021 - nature.com
… Here we conduct a multi-ancestry, genome-wide genetic discovery meta-analysis of lipid
levels in approximately 1.65 million individuals, including 350,000 of non-European ancestries. …

[HTML][HTML] Statistical methods for Mendelian randomization in genome-wide association studies: a review

FJ Boehm, X Zhou - Computational and structural biotechnology journal, 2022 - Elsevier
… that uses SNP associations from genome-wide association studies as instruments to study
… in parallel with the growth of genome-wide association studies. We argue that the recent …

[HTML][HTML] Gene–environment correlations across geographic regions affect genome-wide association studies

A Abdellaoui, CV Dolan, KJH Verweij, MG Nivard - Nature Genetics, 2022 - nature.com
… Gene–environment correlations affect associations between genetic variants and complex
traits in genome-wide association studies (GWASs). Here we showed in up to 43,516 British …

[HTML][HTML] Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

DL McCartney, JL Min, RC Richmond, AT Lu… - Genome biology, 2021 - Springer
… Leveraging DNA methylation and SNP data from more than 40,000 individuals, we identify
137 genome-wide significant loci, of which 113 are novel, from genome-wide association